Published on
March 26, 2023

Top 10 Startups in Philadelphia

Maximilian Fleitmann
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Philadelphia is a city known for its history, sports, and delicious food. But did you know it's quickly becoming a startup hub as well? There are companies springing up all over the city that could be your next big client.

The 10 best Startups in Philadelphia

1. Gopuff


Gopuff is a Philadelphia-based company that delivers products like over-the-counter medicine, baby food, and alcohol. Across America, Gopuff is known for satiating late-night cravings for Ben and Jerry’s ice cream, Doritos, Red Bull, and, in select markets, White Claw and rescuing those in need of diapers, condoms, and cleaning products. Gopuff allows users the joy of browsing the shelves without the hassle of going to the store. It takes seconds to navigate the app and minutes for Gopuff’s Driver-Partners to deliver the customer’s needs and wants.The company was founded in 2013 by Yakir Gola and Rafael Ilishayev, two Drexel University students with a minivan and a vision to make everyday life a little easier.


Founded: 2013

Total Funding: $3.4B

Last Funding Type: Seed

2. Tmunity Therapeutics

Startup_Philadelphia_Tmunity Therapeutics

Tmunity Therapeutics is developing novel products to unleash the immunological potential of T cells to treat a wide range of disease indications. Tmunity is developing novel T Cell Receptor (TCR) engineered T cells, regulatory T cells (Treg), and universal engineered T cell platforms that exhibit best-in-class control over T cell activation and direction in vivo, as well as proprietary technologies to activate, expand, and genetically engineer T cells from peripheral blood, cord blood and tumors. The company is rapidly advancing toward the clinic personalized next-generation immunotherapies for oncology, infectious diseases and autoimmune disease. The founding team includes experts in T-cell biology, manufacturing, regulatory affairs, and clinical development, who collectively have an unparalleled track record of executing safe and effective cell and gene therapy clinical trials. In addition, Tmunity’s manufacturing platform has a proven track record of success in supporting multi-center clinical studies across diverse therapeutic indications.


Founded: 2015

Total Funding: $230M

Last Funding Type: Series B

3. Imvax


Imvax is a biotechnology company focused on the development of novel patient-specific vaccines and immunotherapy strategies for the treatment of malignant gliomas and other cancers with unmet medical needs.Its product, IGV-001, is an autologous tumor cell vaccine that delivers a multi-pronged response against tumor cells by leveraging the patient’s immune system as a defense mechanism.The company was incorporated in 2015 by David W. Andrews, Craig Hooper, Arthur W. Howe, and Peter B. Corr in Philadelphia, Pennsylvania.


Founded: 2015

Total Funding: $166.7M

Last Funding Type: Series C

4. Carisma Therapeutics

Startup_Philadelphia_Carisma Therapeutics

Carisma Therapeutics is a biotech company that develops novel chimeric antigen receptor macrophage technology to treat solid tumors. Its cell therapies apply powerful chimeric antigen receptor technology and adoptive cell transfer in cancer therapy and to macrophages that infiltrate the solid tumor micro-environment that enables solid tumorpatients to receive strong cellular immunotherapy and cancer treatments. The company's technology leverages advances in macrophage biology, chimeric antigen receptor engineering, and adoptive cellular therapy for the treatment of human disease.Founded in 2016 by Michael Klichinsky and Saar Gill, Carisma Therapeutics is headquartered in Philadelphia, Pennsylvania.


Founded: 2016

Total Funding: $151.9M

Last Funding Type: Series C

5. HealthVerity


HealthVerity is a provider of technologies and software tools that enable healthcare providers, such as Pharmaceutical manufacturers, Hospitals and Payers, to discover, license and integrate patient data from a wide range of traditional and emerging data sources to build the optimal patient data set. It serves as the foundation for the rapidcreation, exchange, and management of healthcare and consumer data in a fully-interoperable, privacy-protecting manner. Advantaged by highly sophisticated identity resolution and matching capabilities, HealthVerity aims to increase transparency and activate deeper insights across the healthcare industry.It was founded in 2014 and is headquartered in Philadelphia, Pennsylvania.Lists Featuring This Company


Founded: 2014

Total Funding: $142.2M

Last Funding Type: Series D

6. Aro Biotherapeutics

Startup_Philadelphia_Aro Biotherapeutics

Aro Biotherapeutics is focused on the development of a new protein drug platform called Centyrins, designed to achieve better efficacy and safety profiles for patients with cancer and other serious diseases. Centyrins are small, non-antibody protein scaffolds that can be expressed as multi-specifics with novel therapeutic mechanisms of action.


Founded: 2017

Total Funding: $125M

Last Funding Type: Series B

7. Crossbeam


Crossbeam is a collaborative data platform that helps companies build more valuable partnerships. It acts as an escrow service for data, allowing companies to find overlapping customers and prospects with their partners while keeping the rest of their data private and secure. Their collaborative intelligence platform allows B2B companies to securely share their data to strengthen alliances, enable go-to-market teams, and better serve their customers.


Founded: 2018

Total Funding: $116.9M

Last Funding Type: Series C



iECURE is a mutation-agnostic in vivo gene editing company striving to cure devastating diseases with high unmet needs.


Founded: 2012

Total Funding: $115M

Last Funding Type: Series A

9. Vitara Biomedical

Startup_Philadelphia_Vitara Biomedical

Vitara Biomedical has developed a therapeutic platform to support premature infants. Vitara Biomedical's platform was inspired by natural physiological processes to transform neonatal care.


Founded: 2019

Total Funding: $100M

Last Funding Type: Series B

10. Interius BioTherapeutics

Startup_Philadelphia_Interius BioTherapeutics

Interius BioTherapeutics is a biopharmaceutical company that targets cancer. The company spun out the University of Pennsylvania and is targeting cancer.


Founded: 2019

Total Funding: $81.5M

Last Funding Type: Series A

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